In PDAC, the release of Shh from tumor cells is necessary to promote a tumor-permissive microenvironment. ![]() ![]() After processing, Shh remains at the plasma membrane of Shh producing cells, thereby limiting its distribution and signal strength. Background: Sonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC).
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